| Domingo 17 de marzo de 2019 | |||||
| 18:00 | Brujas |  | 1 - 2 |  | Royal Excel Mouscron |
| 18:00 | Standard de Lieja |  | 4 - 3 |  | Waasland-Beveren |
| 18:00 | Kortrijk |  | 2 - 0 |  | Antwerp |
| 18:00 | KV Oostende |  | 0 - 2 |  | Anderlecht |
| 18:00 | Zulte-Waregem |  | 3 - 3 |  | Genk |
| 18:00 | Lokeren |  | 3 - 1 |  | Círculo de Brujas |
| 18:00 | Sporting Charleroi |  | 1 - 2 |  | AS Eupen |
| 18:00 | Sint-Truiden |  | 0 - 2 |  | Gent |
